Annals of Colorectal Research Annals of Colorectal Research Ann Colorectal Res http://www.colorectalresearch.com 2322-5262 2322-5289 10.5812/acr. en jalali 2017 6 24 gregorian 2017 6 24 2 4
en 10.17795/acr-25188 The Healing Effect of Hypericum perforatum Extract on Acetic Acid-Induced Ulcerative Colitis in Rat The Healing Effect of <italic>Hypericum perforatum</italic> Extract on Acetic Acid-Induced Ulcerative Colitis in Rat research-article research-article Background

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD). There are several chemical and herbal drug regimens for treatment of UC.

Objectives

The aims of this study were to investigate the effects of Hypericum perforatum on histopathological and tissue malondialdehyde (MDA) level of colonic tissue in rat with induced UC.

Materials and Methods

Two milliliters of 3% acetic acid was administered into the colon to induce UC. Seventy rats were divided into seven equal groups. Groups I and II received 1 mL of 600 and 300 mg/kg H. perforatum extract orally per day respectively; groups III and IV received 1 mL of 20% and 10% intra-colonic gel form of H. perforatum extract daily respectively; group V as positive control received 2 mL of intra-colonic asacol; group VI was a negative control receiving 0.5 mL/kg of normal saline after induction of UC; group VII received just intra-colonic gel base. All the animals were evaluated for histological changes and tissue MDA level seven days after the treatment.

Results

H. perforatum extract in the two forms of trans-rectal and oral administration on the seventh day after the therapy could result in a more healing effect on acetic acid-induced damaged colonic tissue with a reduction in the MDA activity. In trans-rectal administration, the 20% gel form had a better healing response than the 10% gel form and was prominently more effect on the seventh day of the therapy. In oral administration of strawberry extract, the 600 mg/kg dosage had a better healing response than the 300 mg/kg and was significantly more effective on the seventh day of therapy.

Conclusions

So H. perforatum may be considered as a treatment of choice for UC especially in gel form to broaden the current therapy options of the disease.

Background

Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD). There are several chemical and herbal drug regimens for treatment of UC.

Objectives

The aims of this study were to investigate the effects of Hypericum perforatum on histopathological and tissue malondialdehyde (MDA) level of colonic tissue in rat with induced UC.

Materials and Methods

Two milliliters of 3% acetic acid was administered into the colon to induce UC. Seventy rats were divided into seven equal groups. Groups I and II received 1 mL of 600 and 300 mg/kg H. perforatum extract orally per day respectively; groups III and IV received 1 mL of 20% and 10% intra-colonic gel form of H. perforatum extract daily respectively; group V as positive control received 2 mL of intra-colonic asacol; group VI was a negative control receiving 0.5 mL/kg of normal saline after induction of UC; group VII received just intra-colonic gel base. All the animals were evaluated for histological changes and tissue MDA level seven days after the treatment.

Results

H. perforatum extract in the two forms of trans-rectal and oral administration on the seventh day after the therapy could result in a more healing effect on acetic acid-induced damaged colonic tissue with a reduction in the MDA activity. In trans-rectal administration, the 20% gel form had a better healing response than the 10% gel form and was prominently more effect on the seventh day of the therapy. In oral administration of strawberry extract, the 600 mg/kg dosage had a better healing response than the 300 mg/kg and was significantly more effective on the seventh day of therapy.

Conclusions

So H. perforatum may be considered as a treatment of choice for UC especially in gel form to broaden the current therapy options of the disease.

Hypericum perforatum;Inflammatory Bowel Disease;Ulcerative Colitis;Malondialdehyde Hypericum perforatum;Inflammatory Bowel Disease;Ulcerative Colitis;Malondialdehyde http://www.colorectalresearch.com/index.php?page=article&article_id=25188 Nader Tanideh Nader Tanideh Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Seyedeh Leila Nematollahi Seyedeh Leila Nematollahi Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran Student Research Committee, Shiraz University of Medical Sciences, Shiraz, IR Iran Seyed Vahid Hosseini Seyed Vahid Hosseini Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Masood Hosseinzadeh Masood Hosseinzadeh Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran Davood Mehrabani Davood Mehrabani Stem Cells and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Stem Cells and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Alireza Safarpour Alireza Safarpour Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Masood Sepehrimanesh Masood Sepehrimanesh Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel/Fax: +98-7136474263 Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel/Fax: +98-7136474263 Omid Koohi-Hosseinabadi Omid Koohi-Hosseinabadi Center of Experimental and Comparative Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran Center of Experimental and Comparative Medicine, Shiraz University of Medical Sciences, Shiraz, IR Iran Asma Najibi Asma Najibi Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IR Iran
en 10.17795/acr-25741 Conservative Management of Anterior Abdominal Penetrating Trauma Conservative Management of Anterior Abdominal Penetrating Trauma research-article research-article Results

Among 45 patients who underwent nonoperative management, 27 cases (60%) required laparotomy due to peritonitis or shock. Rate of unnecessary nontherapeutic operations was 49.2%.

Conclusions

Minimizing diagnostic procedures such as diagnostic peritoneal lavage and computed tomography can significantly increase the rate of unnecessary operations leading to longer hospitalizations and operation-related morbidity. To reduce the failure rate of nonoperative management and nontherapeutic surgeries, modifications in current guidelines should be made.

Background

Selective conservative management of abdominal penetrating trauma can significantly minimize the morbidity and length of hospitalization by decreasing the rate of unnecessary laparotomies.

Patients and Methods

All patients with anterior abdominal stab wounds who were referred to Rajaiee trauma center between September 2012 and September 2013 were enrolled. Patients without shock, peritonitis, and evisceration who did not require emergency operation were planned for nonoperative management with serial physical examinations, blood cells count, and radiographic investigations. Outcome of nonoperative management was described in order to reveal the advantages and disadvantages of our current guideline.

Objectives

In the present study, we reported the outcome of newest guidelines of our trauma center in one year.

Results

Among 45 patients who underwent nonoperative management, 27 cases (60%) required laparotomy due to peritonitis or shock. Rate of unnecessary nontherapeutic operations was 49.2%.

Conclusions

Minimizing diagnostic procedures such as diagnostic peritoneal lavage and computed tomography can significantly increase the rate of unnecessary operations leading to longer hospitalizations and operation-related morbidity. To reduce the failure rate of nonoperative management and nontherapeutic surgeries, modifications in current guidelines should be made.

Background

Selective conservative management of abdominal penetrating trauma can significantly minimize the morbidity and length of hospitalization by decreasing the rate of unnecessary laparotomies.

Patients and Methods

All patients with anterior abdominal stab wounds who were referred to Rajaiee trauma center between September 2012 and September 2013 were enrolled. Patients without shock, peritonitis, and evisceration who did not require emergency operation were planned for nonoperative management with serial physical examinations, blood cells count, and radiographic investigations. Outcome of nonoperative management was described in order to reveal the advantages and disadvantages of our current guideline.

Objectives

In the present study, we reported the outcome of newest guidelines of our trauma center in one year.

Wounds;Abdomen;Trauma Wounds;Abdomen;Trauma http://www.colorectalresearch.com/index.php?page=article&article_id=25741 Shahram Paydar Shahram Paydar Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Parsa Ravanfar Parsa Ravanfar Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-9393039324, Fax: +98-7136293620 Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-9393039324, Fax: +98-7136293620 Vahid Shakoori Vahid Shakoori Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Trauma Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
en 10.17795/acr-25656 Foramen of Winslow Hernia: A Case Report and Literature Review Foramen of Winslow Hernia: A Case Report and Literature Review case-report case-report Introduction

Foramen of Winslow hernia is a rare occurrence, accounting for only 8% of all internal hernias and 0.08% of all hernias. It presents a diagnostic challenge with subtle clinical and radio - logical features. A delay in treatment is responsible for high mortality rates of around 36 - 49%.

Case Presentation

Here we describe a case of a 31-year-old man who presented with acute epigastric pain. Extensive diagnostic work - up suggested foramen of Winslow hernia. At laparotomy, the herniated small bowel was viable and reduction was achieved with gentle traction.

Conclusions

Successful management of foramen of Winslow hernia requires prompt diagnosis and surgical treatment.

Introduction

Foramen of Winslow hernia is a rare occurrence, accounting for only 8% of all internal hernias and 0.08% of all hernias. It presents a diagnostic challenge with subtle clinical and radio - logical features. A delay in treatment is responsible for high mortality rates of around 36 - 49%.

Case Presentation

Here we describe a case of a 31-year-old man who presented with acute epigastric pain. Extensive diagnostic work - up suggested foramen of Winslow hernia. At laparotomy, the herniated small bowel was viable and reduction was achieved with gentle traction.

Conclusions

Successful management of foramen of Winslow hernia requires prompt diagnosis and surgical treatment.

Small Intestine;Hernia;Peritoneal Cavity Small Intestine;Hernia;Peritoneal Cavity http://www.colorectalresearch.com/index.php?page=article&article_id=25656 Chin Li Tee Chin Li Tee Department of Surgery, Nambour Hospital, Nambour, Australia; Department of Surgery, Nambour Hospital, Nambour, Australia. Tel: +61-75470 6600 Department of Surgery, Nambour Hospital, Nambour, Australia; Department of Surgery, Nambour Hospital, Nambour, Australia. Tel: +61-75470 6600 Bree Stephensen Bree Stephensen Department of Surgery, Nambour Hospital, Nambour, Australia Department of Surgery, Nambour Hospital, Nambour, Australia Thushara Dissanayake Thushara Dissanayake Department of Surgery, Nambour Hospital, Nambour, Australia Department of Surgery, Nambour Hospital, Nambour, Australia David A. Grieve David A. Grieve Department of Surgery, Nambour Hospital, Nambour, Australia Department of Surgery, Nambour Hospital, Nambour, Australia
en 10.17795/acr-25906 To Scan or Not to Scan, That is the Question To Scan or Not to Scan, That is the Question letter letter Radionuclide Imaging;Intestinal Obstruction;Abdomen, Acute Radionuclide Imaging;Intestinal Obstruction;Abdomen, Acute http://www.colorectalresearch.com/index.php?page=article&article_id=25906 Sepideh Sefidbakht Sepideh Sefidbakht Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-71132306972, Fax: +98-7132330724 Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-71132306972, Fax: +98-7132330724 Fariba Zarei Fariba Zarei Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
en 10.17795/acr-25420 Jejunojejunal Intussusception Caused by a Jejunal Villous Adenoma Polyp in an Adult Jejunojejunal Intussusception Caused by a Jejunal Villous Adenoma Polyp in an Adult case-report case-report Introduction

Intussusception is telescoping or invagination of one part of the intestine (intussusception) into an adjacent section (intussuscipiens) and it may present as a life threatening condition. Intussusception is so rare in adults and small intestine intussusception in adults is usually due to benign entity; whereas in large intestine, malignant neoplasms can be the etiology. Here, we reported a rare case of adult jejunojejunal intussusception due to a jejunal villous adenoma polyp in an Iranian female patient.

Case Presentation

A 33-year female Iranian patient referred to emergency department in Gastroenterology and liver diseases Research Center, Shahid Beheshti University of Medical Sciences with extreme abdominal pain, nausea and constipation. Plain abdominal computed tomography (CT) scan revealed a mass suggesting intussusception in the jejunum. Balloon association enteroscopy showed two 10 mm and 40 mm polyps in jejunum. The polyp was a villous adenoma confirmed by pathology. Exploratory laparotomy revealed jejunojejunal intussusceptions and exploratory laparotomy with jejunoileal anastomosis was performed.

Conclusions

Nonspecific symptoms of an adult intussusception might result in a late diagnosis and imaging modalities including CT scan play a significant role in the diagnosis. Surgical operation is the best treatment in adult intussusception leading to the best results.

Introduction

Intussusception is telescoping or invagination of one part of the intestine (intussusception) into an adjacent section (intussuscipiens) and it may present as a life threatening condition. Intussusception is so rare in adults and small intestine intussusception in adults is usually due to benign entity; whereas in large intestine, malignant neoplasms can be the etiology. Here, we reported a rare case of adult jejunojejunal intussusception due to a jejunal villous adenoma polyp in an Iranian female patient.

Case Presentation

A 33-year female Iranian patient referred to emergency department in Gastroenterology and liver diseases Research Center, Shahid Beheshti University of Medical Sciences with extreme abdominal pain, nausea and constipation. Plain abdominal computed tomography (CT) scan revealed a mass suggesting intussusception in the jejunum. Balloon association enteroscopy showed two 10 mm and 40 mm polyps in jejunum. The polyp was a villous adenoma confirmed by pathology. Exploratory laparotomy revealed jejunojejunal intussusceptions and exploratory laparotomy with jejunoileal anastomosis was performed.

Conclusions

Nonspecific symptoms of an adult intussusception might result in a late diagnosis and imaging modalities including CT scan play a significant role in the diagnosis. Surgical operation is the best treatment in adult intussusception leading to the best results.

Intussusception;Surgery;Villous;Tomography Intussusception;Surgery;Villous;Tomography http://www.colorectalresearch.com/index.php?page=article&article_id=25420 Seyed Mohammad Hossein Kashfi Seyed Mohammad Hossein Kashfi Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Faegheh Behboudi Farahbakhsh Faegheh Behboudi Farahbakhsh Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Mina Golmohammadi Mina Golmohammadi Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Ehsan Nazemalhosseini Mojarad Ehsan Nazemalhosseini Mojarad Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Pedram Azimzadeh Pedram Azimzadeh Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Shahrokh Iravani Shahrokh Iravani Aja Cancer Research Center (ACRC), Aja University of Medical Sciences, Tehran, IR Iran Aja Cancer Research Center (ACRC), Aja University of Medical Sciences, Tehran, IR Iran Hamid Asadzadeh Aghdaei Hamid Asadzadeh Aghdaei Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran. Tel: +98-22432515 Basic and Molecular Epidemiology of Gastroenterology Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran; Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran. Tel: +98-22432515 Katayoun Gohari Moghaddam Katayoun Gohari Moghaddam Aja Cancer Research Center (ACRC), Aja University of Medical Sciences, Tehran, IR Iran Aja Cancer Research Center (ACRC), Aja University of Medical Sciences, Tehran, IR Iran Mohammadreza Zali Mohammadreza Zali Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran