Annals of Colorectal Research Annals of Colorectal Research Ann Colorectal Res http://www.colorectalresearch.com 2322-5262 2322-5289 10.5812/acr. en jalali 2017 6 23 gregorian 2017 6 23 3 3
en 10.17795/acr-29093 Perianal Paget’s Disease in a Forty-Five-Year-Old Man and Review of the Literature Perianal Paget’s Disease in a Forty-Five-Year-Old Man and Review of the Literature case-report case-report Conclusions

A good outcome and no recurrence or complications was noticed in a follow-up period of 24 months. It is important to consider this uncommon disease as a probable diagnosis when evaluating a perianal lesion.

Case Presentation

A 45-year-old man presented with perianal itchy lesions for one year with no response to local treatments. Perianal Paget’s disease was diagnosed by performing a surgical biopsy. Wide excision and flap reconstruction was done, while loop sigmoid colostomy was performed for fecal diversion. Re-excision of the involved margins was performed during the second operation.

Introduction

Extramammary Paget’s disease is a rare neoplasm of the skin that might develop in perianal region. Although different management options are available, wide local excision is still the method of choice.

Conclusions

A good outcome and no recurrence or complications was noticed in a follow-up period of 24 months. It is important to consider this uncommon disease as a probable diagnosis when evaluating a perianal lesion.

Case Presentation

A 45-year-old man presented with perianal itchy lesions for one year with no response to local treatments. Perianal Paget’s disease was diagnosed by performing a surgical biopsy. Wide excision and flap reconstruction was done, while loop sigmoid colostomy was performed for fecal diversion. Re-excision of the involved margins was performed during the second operation.

Introduction

Extramammary Paget’s disease is a rare neoplasm of the skin that might develop in perianal region. Although different management options are available, wide local excision is still the method of choice.

Paget Disease Extramammary;Perianal Glands;Local Excision Paget Disease Extramammary;Perianal Glands;Local Excision http://www.colorectalresearch.com/index.php?page=article&article_id=29093 Yavar Shams Hojjati Yavar Shams Hojjati Department of Surgery, Mashhad University of Medical Sciences, Mashhad, IR Iran Department of Surgery, Mashhad University of Medical Sciences, Mashhad, IR Iran Abbas Abdollahi Abbas Abdollahi Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran. Tel: +98-5138022677, Fax: +98- 5138525255 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran; Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran. Tel: +98-5138022677, Fax: +98- 5138525255 Ghodratollah Maddah Ghodratollah Maddah Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran Asieh Sadat Fattahi Asieh Sadat Fattahi Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran
en 10.17795/acr-30100 Molecular Biomarkers of Colorectal Cancer: A Review of Published Articles From Iran Molecular Biomarkers of Colorectal Cancer: A Review of Published Articles From Iran review-article review-article Conclusion

This study showed that molecular biomarkers in colorectal cancer of Iranian patients are not so different from Western population.

Evidence aquisition

In this study, we tried to review published articles about the molecular biomarkers of colorectal cancer from Iran. We searched medical databases such as google scholar, Scopus, PubMed, Magiran, SID and Iran Medex for keywords of “colon cancer, KRAS, BRAF, mismatch repair gene, Microsatellite instability, molecular genetics, molecular pathogenesis, biomarker and Iran” to find studies published about colorectal cancers from Iran regarding molecular biomarkers.

Context

Colorectal cancer is one of the most common cancers worldwide (the third most common cancer in the world) and is especially more common in Western countries; however, its incidence has been increased significantly during the last few years in Eastern countries such as Iran and considered as one of the five common cancers in this country. According to molecular pathways, numerous biomarkers have been identified for colorectal cancers which help patients’ management.

Conclusion

This study showed that molecular biomarkers in colorectal cancer of Iranian patients are not so different from Western population.

Evidence aquisition

In this study, we tried to review published articles about the molecular biomarkers of colorectal cancer from Iran. We searched medical databases such as google scholar, Scopus, PubMed, Magiran, SID and Iran Medex for keywords of “colon cancer, KRAS, BRAF, mismatch repair gene, Microsatellite instability, molecular genetics, molecular pathogenesis, biomarker and Iran” to find studies published about colorectal cancers from Iran regarding molecular biomarkers.

Context

Colorectal cancer is one of the most common cancers worldwide (the third most common cancer in the world) and is especially more common in Western countries; however, its incidence has been increased significantly during the last few years in Eastern countries such as Iran and considered as one of the five common cancers in this country. According to molecular pathways, numerous biomarkers have been identified for colorectal cancers which help patients’ management.

Biological Markers;Colorectal Cancer;Cancer Biological Markers;Colorectal Cancer;Cancer http://www.colorectalresearch.com/index.php?page=article&article_id=30100 Bita Geramizadeh Bita Geramizadeh Department of Pathology, Transplant Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, IR Iran; Department of Pathology, Transplant Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel/Fax: +98-7136683664 Department of Pathology, Transplant Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, IR Iran; Department of Pathology, Transplant Research Center, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel/Fax: +98-7136683664
en 10.17795/acr-30179 Comparison of Infection Incidence Between Appendectomy Skin Incisions Sutured by Nylon and Polyglactin (Vicryl) Comparison of Infection Incidence Between Appendectomy Skin Incisions Sutured by Nylon and Polyglactin (Vicryl) research-article research-article Results

The postsurgical complication and infections rates were similar between the two groups.

Conclusions

Vicryl sutures can safely be used for skin and subcutaneous wound suturing even when our surgery site is not ideally clean.

Objectives

In this study, we compared skin wound infection rate and other complications in two groups of post appendectomy patients whom were treated with two types of suturing materials - conventionally used Nylon and absorbable braided polyglactin (Vicryl) - and wound healing, existence of complication and recovery course of treated patients were surveyed.

Patients and Methods

A total of 130 patients who underwent appendectomy were divided into two groups of 645 members, each. Patients in group A had their incisions closed by separate sutures (mattress method) by vicryl, while patients in group B had their surgical incisions were closed in the same method, by nylon sutures. Any signs and symptoms of surgical site wound infection like inappropriate pain, redness, discharge, bulging, and unhealing wound were checked during hospital stay and on the 7th - 9th day postoperatively.

Background

Suturing quality and reducing its complications and resulting infection have always been a major concern of surgeons. Many of them have prohibited applying polyfilament and absorbable suturing materials.

Results

The postsurgical complication and infections rates were similar between the two groups.

Conclusions

Vicryl sutures can safely be used for skin and subcutaneous wound suturing even when our surgery site is not ideally clean.

Objectives

In this study, we compared skin wound infection rate and other complications in two groups of post appendectomy patients whom were treated with two types of suturing materials - conventionally used Nylon and absorbable braided polyglactin (Vicryl) - and wound healing, existence of complication and recovery course of treated patients were surveyed.

Patients and Methods

A total of 130 patients who underwent appendectomy were divided into two groups of 645 members, each. Patients in group A had their incisions closed by separate sutures (mattress method) by vicryl, while patients in group B had their surgical incisions were closed in the same method, by nylon sutures. Any signs and symptoms of surgical site wound infection like inappropriate pain, redness, discharge, bulging, and unhealing wound were checked during hospital stay and on the 7th - 9th day postoperatively.

Background

Suturing quality and reducing its complications and resulting infection have always been a major concern of surgeons. Many of them have prohibited applying polyfilament and absorbable suturing materials.

Polyglactin 910;Wound Infection;Sutures Polyglactin 910;Wound Infection;Sutures http://www.colorectalresearch.com/index.php?page=article&article_id=30179 Alireza Golchini Alireza Golchini Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Habib Alah Nikzad Jamnani Habib Alah Nikzad Jamnani Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Sajjad Ahmadi Sajjad Ahmadi Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Elham Karimi Elham Karimi Department of Surgery, Nursing Faculty, Shiraz University of Medical Sciences, Shiraz, IR Iran Department of Surgery, Nursing Faculty, Shiraz University of Medical Sciences, Shiraz, IR Iran Saeedeh Pourahmad Saeedeh Pourahmad Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Alireza Safarpour Alireza Safarpour Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Zahra Zabangirfard Zahra Zabangirfard Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran Leila Ghahramani Leila Ghahramani Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran; Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-7136281453 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz , IR Iran; Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-7136281453
en 10.17795/acr-31871 Cryptosporidiosis and Colorectal Cancer Cryptosporidiosis and Colorectal Cancer letter letter Cryptosporidiosis;Cancer;Colon;Rectum Cryptosporidiosis;Cancer;Colon;Rectum http://www.colorectalresearch.com/index.php?page=article&article_id=31871 Sim Sai Tin Sim Sai Tin Shantou Medical Center, Shantou University Medical College, Shantou, China; Shantou Medical Center, Shantou University Medical College, Shantou, China. Tel: +86-1058093720 Shantou Medical Center, Shantou University Medical College, Shantou, China; Shantou Medical Center, Shantou University Medical College, Shantou, China. Tel: +86-1058093720 Viroj Wiwanitkit Viroj Wiwanitkit Tropical Medicine Department, Hainan Medical University, Haikou, China Tropical Medicine Department, Hainan Medical University, Haikou, China
en 10.17795/acr-32500 Melilotus officinalis L. Protects Ulcerative Colitis in Rats <italic>Melilotus officinalis</italic> L. Protects Ulcerative Colitis in Rats letter letter Ulcerative Colitis;Antioxidant;Melilotus officinalis Ulcerative Colitis;Antioxidant;Melilotus officinalis http://www.colorectalresearch.com/index.php?page=article&article_id=32500 Hajar Khazraei Hajar Khazraei Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Seyed Vahid Hosseini Seyed Vahid Hosseini Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-7136281453, Fax: + 98-7132330724 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran; Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran. Tel: +98-7136281453, Fax: + 98-7132330724 Fahimeh Hajhosseini Fahimeh Hajhosseini Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
en 10.17795/acr-32059 Conservative Management of Anterior Abdominal Stab Wounds Conservative Management of Anterior Abdominal Stab Wounds letter letter Abdominal;Management;Wounds, Stab Abdominal;Management;Wounds, Stab http://www.colorectalresearch.com/index.php?page=article&article_id=32059 Seyed Vahid Hosseini Seyed Vahid Hosseini Department of Surgery, Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Department of Surgery, Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Seyed Hesamaddin Banihashemi Seyed Hesamaddin Banihashemi Department of Surgery, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran; Department of Surgery, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran. Tel/fax: +98-7136281453 Department of Surgery, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran; Department of Surgery, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, IR Iran. Tel/fax: +98-7136281453 Shahla Fereidooni Shahla Fereidooni Department of Surgery, Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran Department of Surgery, Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran