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Oral Psyllium Herbal Laxative, Clinical Trial in a Difficult Group


1 Department of Gastroenterology, University Hospitals of Leicester NHS Trust, Leicester, UK
*Corresponding author: John F. Mayberry, Department of Gastroenterology, University Hospitals of Leicester NHS Trust, Leicester, UK, Tel.: +44-1162584786, E-mail: johnfmayberry@yahoo.co.uk.
Annals of Colorectal Research. 2013 September; 1(2) , DOI: 10.17795/acr-14314
Article Type: Letter; Received: Aug 21, 2013; Accepted: Aug 24, 2013; epub: Jul 30, 2013; ppub: Sep 29, 2013

Keywords: Pregnancy; Psyllium; Haemorrhoids; Fissures; Trials

Dear Editor,

It is never easy to conduct a randomised double blind control trial in pregnancy and so the importance of this report cannot be over-emphasised (1). Support for this view comes from the fact that 724 of 3136 (23%) of women invited to take part in the study declined to do so. However the outcome has been to demonstrate clearly that the addition of psyllium to the diet in the third trimester can effectively reduce the painful rectal complications of pregnancy. In the treated group 10 patients (1%) had a fissure or haemorrhoids compared to 138 (13%) in the placebo group (2). Such a benefit should be offered to all pregnant women in their last trimester. In addition there should be long term follow-up of these cases to assess whether this benefit extends to include a reduction in the rates of rectal and vaginal prolapse.

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Financial Disclosure: There is no financial disclosure.

References


  • 1. Amir LH, Lumley J, Garland SM. A failed RCT to determine if antibiotics prevent mastitis: Cracked nipples colonized with Staphylococcus aureus: A randomized treatment trial [ISRCTN65289389]. BMC Pregnancy Childbirth. 2004;4(1):19. [DOI] [PubMed]
  • 2. Ghahramani L, Hosseini SV, Rahimikazerooni S, Bananzadeh AM, Namavar Jahromi B, Samsam A, et al. The Effect of Oral Psyllium Herbal Laxative Powder in Prevention of Hemorrhoids and Anal Fissure during Pregnancy, a Randomized Double Blind Clinical Trial. Ann Colorectal Res. 2013;1(1):23-7. [DOI]