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Cryptosporidiosis and Colorectal Cancer

1 Shantou Medical Center, Shantou University Medical College, Shantou, China
2 Tropical Medicine Department, Hainan Medical University, Haikou, China
*Corresponding author: Sim Sai Tin, Shantou Medical Center, Shantou University Medical College, Shantou, China. Tel: +86-1058093720, E-mail:
Annals of Colorectal Research. 3(3): e31871 , DOI: 10.17795/acr-31871
Article Type: Letter; Received: Jul 27, 2015; Accepted: Aug 2, 2015; epub: Oct 15, 2015; collection: Oct 2015

Keywords: Cryptosporidiosis; Cancer; Colon; Rectum

Dear Editor,

Colorectal parasitosis is of great significance in the tropical world (1), where several parasitic infestations can be seen. However, an interesting concern is the interrelationship between parasitic infestation and colorectal cancer. Of several parasites, Cryptosporidium spp. is widely mentioned. A high prevalence of cryptosporidiosis has been observed in cases with colorectal cancer (2, 3). In fact, the interrelationship was proposed a long time ago: Izquierdo et al. (4) were first to mention it in their observation: “Diarrhea caused by Cryptosporidium and colonic neoplasia.”. At the time, there was very little interest in this topic; nevertheless, the emergence of the HIV infection turned cryptosporidiosis into a common clinical problem and raised concern over the interrelationship between cryptosporidiosis and colorectal cancer. Shebl et al. (5) studied AIDS cases and noted: “Cryptosporidiosis was associated with rare colon squamous cell carcinoma…” Nonetheless, the exact pathophysiology has never been proved. Recently, Abdou et al. (6) studied an animal model and reported that the parasite might trigger cellular dysplasia. The exact pathophysiological process of the possible carcinogenesis in cryptosporidiosis is an important topic for further research.


Authors’ Contributions: Sim Sai Tin came up with 90% of the idea, wrote, and approved the final paper. Viroj Wiwanitkit was responsible for 10% of the idea and approved the final paper.


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