Annals of Colorectal Research

Published by: Kowsar

Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin

Francisco Javier Perez Lara 1 , * , Arminda Ferrer Berges 1 , Jose Manuel Hernandez Gonzalez 1 , Elena Sanchis Cardenas 1 , Arturo del Rey Moreno 1 and Horacio Oliva Munoz 1
Authors Information
1 Digestive Surgery Department, Antequera Hospital, Malaga, Spain
Article information
  • Annals of Colorectal Research: September 01, 2016, 4 (3); e37452
  • Published Online: August 22, 2016
  • Article Type: Brief Report
  • Received: February 27, 2016
  • Revised: August 11, 2016
  • Accepted: August 17, 2016
  • DOI: 10.17795/acr-37452

To Cite: Perez Lara F J, Ferrer Berges A, Manuel Hernandez Gonzalez J, Sanchis Cardenas E, del Rey Moreno A, et al. Method for Management of Perianal Fistula with New Device: Progressive Curettage of the Tract and Sealing with Platelet-Rich Fibrin, Ann Colorectal Res. 2016 ; 4(3):e37452. doi: 10.17795/acr-37452.

Copyright © 2016, Colorectal Research Center and Health Policy Research Center of Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Surgical Technique
3. Discussion
  • 1. Zanotti C, Martinez-Puente C, Pascual I, Pascual M, Herreros D, Garcia-Olmo D. An assessment of the incidence of fistula-in-ano in four countries of the European Union. Int J Colorectal Dis. 2007; 22(12): 1459-62[DOI][PubMed]
  • 2. Lunniss PJ, Kamm MA, Phillips RK. Factors affecting continence after surgery for anal fistula. Br J Surg. 1994; 81(9): 1382-5[PubMed]
  • 3. Hammond TM, Knowles CH, Porrett T, Lunniss PJ. The Snug Seton: short and medium term results of slow fistulotomy for idiopathic anal fistulae. Colorectal Dis. 2006; 8(4): 328-37[DOI][PubMed]
  • 4. Dziki A, Bartos M. Seton treatment of anal fistula: experience with a new modification. Eur J Surg. 1998; 164(7): 543-8[DOI][PubMed]
  • 5. Ho YH, Tan M, Chui CH, Leong A, Eu KW, Seow-Choen F. Randomized controlled trial of primary fistulotomy with drainage alone for perianal abscesses. Dis Colon Rectum. 1997; 40(12): 1435-8[PubMed]
  • 6. Byrne CM, Solomon MJ. The Use of Setons in Fistula-in-Ano. Semin Colon Rectal Surg. 2009; 20(1): 10-7[DOI]
  • 7. van Koperen PJ, Wind J, Bemelman WA, Bakx R, Reitsma JB, Slors JF. Long-term functional outcome and risk factors for recurrence after surgical treatment for low and high perianal fistulas of cryptoglandular origin. Dis Colon Rectum. 2008; 51(10): 1475-81[DOI][PubMed]
  • 8. Cox SW, Senagore AJ, Luchtefeld MA, Mazier WP. Outcome after incision and drainage with fistulotomy for ischiorectal abscess. Am Surg. 1997; 63(8): 686-9[PubMed]
  • 9. Vaizey CJ, Carapeti E, Cahill JA, Kamm MA. Prospective comparison of faecal incontinence grading systems. Gut. 1999; 44(1): 77-80[PubMed]
  • 10. Ellis CN. Sphincter-preserving fistula management: what patients want. Dis Colon Rectum. 2010; 53(12): 1652-5[DOI][PubMed]
  • 11. Perez Lara FJ, Hernandez Carmona JM, Del Rey Moreno A, Oliva Munoz H. Cylindrical curettes for the treatment of complex perianal fistulas. Dis Colon Rectum. 2014; 57(9): 1140[DOI][PubMed]
  • 12. Sonoda T, Hull T, Piedmonte MR, Fazio VW. Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap. Dis Colon Rectum. 2002; 45(12): 1622-8[DOI][PubMed]
  • 13. van der Hagen SJ, Baeten CG, Soeters PB, Beets-Tan RG, Russel MG, van Gemert WG. Staged mucosal advancement flap for the treatment of complex anal fistulas: pretreatment with noncutting Setons and in case of recurrent multiple abscesses a diverting stoma. Colorectal Dis. 2005; 7(5): 513-8[DOI][PubMed]
  • 14. Hjortrup A, Moesgaard F, Kjaergard J. Fibrin adhesive in the treatment of perineal fistulas. Dis Colon Rectum. 1991; 34(9): 752-4[PubMed]
  • 15. Champagne BJ, O'Connor LM, Ferguson M, Orangio GR, Schertzer ME, Armstrong DN. Efficacy of anal fistula plug in closure of cryptoglandular fistulas: long-term follow-up. Dis Colon Rectum. 2006; 49(12): 1817-21[DOI][PubMed]
  • 16. Herreros MD, Garcia-Arranz M, Guadalajara H, De-La-Quintana P, Garcia-Olmo D, Fatt Collaborative Group . Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation. Dis Colon Rectum. 2012; 55(7): 762-72[DOI][PubMed]
  • 17. Prosst RL, Herold A, Joos AK, Bussen D, Wehrmann M, Gottwald T, et al. The anal fistula claw: the OTSC clip for anal fistula closure. Colorectal Dis. 2012; 14(9): 1112-7[DOI][PubMed]
  • 18. Maralcan G, Baskonus I, Aybasti N, Gokalp A. The use of fibrin glue in the treatment of fistula-in-ano: a prospective study. Surg Today. 2006; 36(2): 166-70[DOI][PubMed]
  • 19. Ross R, Glomset J, Kariya B, Harker L. A platelet-dependent serum factor that stimulates the proliferation of arterial smooth muscle cells in vitro. Proc Natl Acad Sci U S A. 1974; 71(4): 1207-10[PubMed]
  • 20. Eppley BL, Woodell JE, Higgins J. Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plast Reconstr Surg. 2004; 114(6): 1502-8[PubMed]
  • 21. Li Q, Pan S, Dangaria SJ. Platelet-rich fibrin promotes periodontal regeneration and enhances alveolar bone augmentation. . Biomed Res Int. 2013; 2013: 1-13
  • 22. Singh A, Kohli M, Gupta N. Platelet rich fibrin: a novel approach for osseous regeneration. J Maxillofac Oral Surg. 2012; 11(4): 430-4[DOI][PubMed]
  • 23. O'Connell SM, Impeduglia T, Hessler K, Wang XJ, Carroll RJ, Dardik H. Autologous platelet-rich fibrin matrix as cell therapy in the healing of chronic lower-extremity ulcers. Wound Repair Regen. 2008; 16(6): 749-56[DOI][PubMed]
  • 24. Lara FJ, Serrano AM, Moreno JU, Carmona JH, Marquez MF, Perez LR, et al. Platelet-rich fibrin sealant as a treatment for complex perianal fistulas: a multicentre study. J Gastrointest Surg. 2015; 19(2): 360-8[DOI][PubMed]
  • 25. Buchanan GN, Sibbons P, Osborn M, Bartram CI, Ansari T, Halligan S, et al. Pilot study: fibrin sealant in anal fistula model. Dis Colon Rectum. 2005; 48(3): 532-9[DOI][PubMed]
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