Annals of Colorectal Research

Published by: Kowsar

Perianal Paget’s Disease in a Forty-Five-Year-Old Man and Review of the Literature

Yavar Shams Hojjati 1 , Abbas Abdollahi 2 , * , Ghodratollah Maddah 3 and Asieh Sadat Fattahi 3
Authors Information
1 Department of Surgery, Mashhad University of Medical Sciences, Mashhad, IR Iran
2 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran
3 Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran
Article information
  • Annals of Colorectal Research: June 8, 2015, 3 (3); e60089
  • Published Online: June 1, 2015
  • Article Type: Case Report
  • Received: April 7, 2015
  • Revised: May 6, 2015
  • Accepted: May 19, 2015
  • DOI: 10.17795/acr-29093

To Cite: Shams Hojjati Y, Abdollahi A, Maddah G, Fattahi A S. Perianal Paget’s Disease in a Forty-Five-Year-Old Man and Review of the Literature, Ann Colorectal Res. 2015 ; 3(3):e60089. doi: 10.17795/acr-29093.

Copyright © 2015, Colorectal Research Center and Health Policy Research Center of Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Introduction
2. Case Presentation
3. Discussion
  • 1. Rao VR, Henry DH. Extramammary Paget's disease. Commun Oncol. 2004; 1(2): 109-14
  • 2. Vergati M, Filingeri V, Palmieri G, Roselli M. Perianal Paget's disease: a case report and literature review. Anticancer Res. 2012; 32(10): 4461-5[PubMed]
  • 3. Zollo JD, Zeitouni NC. The Roswell Park Cancer Institute experience with extramammary Paget's disease. Br J Dermatol. 2000; 142(1): 59-65[PubMed]
  • 4. Shepherd V, Davidson EJ, Davies-Humphreys J. Extramammary Paget's disease. BJOG. 2005; 112(3): 273-9[PubMed]
  • 5. Lian P, Gu WL, Zhang Z, Cai GX, Wang MH, Xu Y, et al. Retrospective analysis of perianal Paget's disease with underlying anorectal carcinoma. World J Gastroenterol. 2010; 16(23): 2943-8[PubMed]
  • 6. Beck DE, Fazio VW. Perianal Paget's disease. Dis Colon Rectum. 1987; 30(4): 263-6
  • 7. Wood WS, Culling CF. Perianal Paget disease. Histochemical differentiation utilizing the borohydride-KOH-PAS reaction. Arch Pathol. 1975; 99(8): 442-5[PubMed]
  • 8. Yoshii N, Kitajima S, Yonezawa S, Matsukita S, Setoyama M, Kanzaki T. Expression of mucin core proteins in extramammary Paget's disease. Pathol Int. 2002; 52(5-6): 390-9[PubMed]
  • 9. Mengjun B, Zheng-Qiang W, Tasleem MM. Extramammary Paget's disease of the perianal region: a review of the literature emphasizing management. Dermatol Surg. 2013; 39(1 Pt 1): 69-75[DOI][PubMed]
  • 10. Paget J. On disease of the mammary areola preceding cancer of the mammary gland. Cancer J Clin. 1971; 21(5): 303-4
  • 11. Crocker HR. Paget's disease, affecting the scrotum and penis. Trans Pathol Soc (London) 1888–1889. 1889; 40: 87-191
  • 12. Dubreuilh W. Paget's disease of the vulva. Br J Dermatology. 1901; 13(11): 407-13
  • 13. Demitsu T, Gonda K, Tanita M, Takahira K, Inoue T, Okada O, et al. Extramammary Paget's disease in two siblings. Br J Dermatol. 1999; 141(5): 951-3[PubMed]
  • 14. Popiolek DA, Hajdu SI, Gal D. Synchronous Paget's disease of the vulva and breast. Gynecol Oncol. 1998; 71(1): 137-40[DOI][PubMed]
  • 15. Chanda JJ. Extramammary Paget's disease: prognosis and relationship to internal malignancy. J Am Acad Dermatol. 1985; 13(6): 1009-14
  • 16. Balducci L, Crawford ED, Smith GF, Lambuth B, McGehee R, Hardy C. Extramammary Paget's disease: an annotated review. Cancer Invest. 1988; 6(3): 293-303[PubMed]
  • 17. Lloyd J, Flanagan AM. Mammary and extramammary Paget's disease. J Clin Pathol. 2000; 53(10): 742-9[PubMed]
  • 18. Goldblum JR, Hart WR. Perianal Paget's disease: a histologic and immunohistochemical study of 11 cases with and without associated rectal adenocarcinoma. Am J Surg Pathol. 1998; 22(2): 170-9
  • 19. Helm KF, Goellner JR, Peters MS. Immunohistochemical stains in extramammary Paget's disease. Am J Dermatopathol. 1992; 14(5): 402-7[PubMed]
  • 20. Fujimoto A, Takata M, Hatta N, Takehara K. Expression of structurally unaltered androgen receptor in extramammary Paget's disease. Lab Invest. 2000; 80(9): 1465-71[PubMed]
  • 21. McCarter MD, Quan SHQ, Busam K, Paty PP, Wong D, Guillem JG. Long-term outcome of perianal Paget’s disease. Dis Colon Rectum. 2003; 46(5): 612-6
  • 22. Mohs FE, Blanchard L. Microscopically controlled surgery for extramammary Paget's disease. Arch Dermatol. 1979; 115(6): 706-8[PubMed]
  • 23. Brown RS, Lankester KJ, McCormack M, Power DA, Spittle MF. Radiotherapy for perianal Paget's disease. Clin Oncol (R Coll Radiol). 2002; 14(4): 272-84[PubMed]
  • 24. Balducci L, Athar M, Smith GF, Khansur T, McKenzie D, Crawford ED. Metastatic extramammary Paget's disease: dramatic response to combined modality treatment. J Surg Oncol. 1988; 38(1): 38-44[PubMed]
  • 25. Runfola MA, Weber TK, Rodriguez-Bigas MA, Dougherty TJ, Petrelli NJ. Photodynamic therapy for residual neoplasms of the perianal skin. Dis Colon Rectum. 2000; 43(4): 499-502[PubMed]
  • 26. Becker-Wegerich PM, Fritsch C, Schulte KW, Megahed M, Neuse W, Goerz G, et al. Carbon dioxide laser treatment of extramammary Paget's disease guided by photodynamic diagnosis. Br J Dermatol. 1998; 138(1): 169-72[PubMed]
  • 27. Shutze WP, Gleysteen JJ. Perianal Paget's disease. Classification and review of management: report of two cases. Dis Colon Rectum. 1990; 33(6): 502-7[PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments