Annals of Colorectal Research

Published by: Kowsar

Incidence of Ulcerative Colitis Relapse: A Prospective Cohort Study in Southern Iran

Seyed Vahid Hosseini 1 , Seyed Alireza Taghavi 2 , Peyman Jafari 3 , Abbas Rezaianzadeh 1 , Maryam Moini 2 , Manoosh Mehrabi 2 , Masood Sepehrimanesh 2 and Ali Reza Safarpour 2 , *
Authors Information
1 Colorectal Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
2 Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IR Iran
3 Biostatistics Ward, Medical School, Shiraz University of Medical Sciences, Shiraz, IR Iran
Article information
  • Annals of Colorectal Research: March 01, 2016, 4 (1); e34565
  • Published Online: March 26, 2016
  • Article Type: Research Article
  • Received: November 10, 2015
  • Revised: February 27, 2016
  • Accepted: March 19, 2016
  • DOI: 10.17795/acr-34565

To Cite: Hosseini S V, Taghavi S A, Jafari P, Rezaianzadeh A, Moini M, et al. Incidence of Ulcerative Colitis Relapse: A Prospective Cohort Study in Southern Iran, Ann Colorectal Res. 2016 ; 4(1):e34565. doi: 10.17795/acr-34565.

Copyright © 2016, Colorectal Research Center and Health Policy Research Center of Shiraz University of Medical Sciences. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Background
2. Objectives
3. Patients and Methods
4. Results
5. Discussion
  • 1. Feuerstein JD, Cheifetz AS. Ulcerative colitis: epidemiology, diagnosis, and management. Mayo Clin Proc. 2014; 89(11): 1553-63[DOI][PubMed]
  • 2. Hosseini SV, Jafari P, Taghavi SA, Safarpour AR, Rezaianzadeh A, Moini M, et al. Fecal Calprotectin is an Accurate Tool and Correlated to Seo Index in Prediction of Relapse in Iranian Patients With Ulcerative Colitis. Iran Red Crescent Med J. 2015; 17(2)[DOI][PubMed]
  • 3. Daryani NE, Bashashati M, Aram S, Hashtroudi AA, Shakiba M, Sayyah A, et al. Pattern of relapses in Iranian patients with ulcerative colitis. A prospective study. J Gastrointestin Liver Dis. 2006; 15(4): 355-8[PubMed]
  • 4. Langholz E, Munkholm P, Davidsen M, Binder V. Course of ulcerative colitis: analysis of changes in disease activity over years. Gastroenterology. 1994; 107(1): 3-11[PubMed]
  • 5. Mantzaris GJ. Medical Therapy of Ulcerative Colitis. 2014; : 417-30[DOI]
  • 6. Ng SC. Epidemiology of inflammatory bowel disease: focus on Asia. Best Pract Res Clin Gastroenterol. 2014; 28(3): 363-72[DOI][PubMed]
  • 7. Yang H, Li Y, Wu W, Sun Q, Zhang Y, Zhao W, et al. The incidence of inflammatory bowel disease in Northern China: a prospective population-based study. PLoS One. 2014; 9(7)[DOI][PubMed]
  • 8. Aghazadeh R, Zali MR, Bahari A, Amin K, Ghahghaie F, Firouzi F. Inflammatory bowel disease in Iran: a review of 457 cases. J Gastroenterol Hepatol. 2005; 20(11): 1691-5[DOI][PubMed]
  • 9. Vahedi H, Merat S, Momtahen S, Olfati G, Kazzazi AS, Tabrizian T, et al. Epidemiologic characteristics of 500 patients with inflammatory bowel disease in Iran studied from 2004 through 2007. Arch Iran Med. 2009; 12(5): 454-60[PubMed]
  • 10. Yazdanbod A, Farzaneh E, Pourfarzi F, Azami A, Mostafazadeh B, Adiban V, et al. Epidemiologic profile and clinical characteristics of ulcerative colitis in northwest of Iran: a 10-year review. Trop Gastroenterol. 2010; 31(4): 308-11[PubMed]
  • 11. Riley SA, Mani V, Goodman MJ, Lucas S. Why do patients with ulcerative colitis relapse? Gut. 1990; 31(2): 179-83[PubMed]
  • 12. Taghavi SA, Safarpour AR, Hosseini SV, Noroozi H, Safarpour M, Rahimikazerooni S. Epidemiology of Inflammatory Bowel Diseases (IBD) in Iran: A Review of 740 Patients in Fars Province, Southern Iran. Ann Colorectal Res. 2013; 1(1): 17-22[DOI]
  • 13. Truelove SC, Witts LJ. Cortisone in ulcerative colitis; final report on a therapeutic trial. Br Med J. 1955; 2(4947): 1041-8[PubMed]
  • 14. Bitton A, Peppercorn MA, Antonioli DA, Niles JL, Shah S, Bousvaros A, et al. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology. 2001; 120(1): 13-20[PubMed]
  • 15. Henriksen M, Jahnsen J, Lygren I, Sauar J, Kjellevold O, Schulz T, et al. Ulcerative colitis and clinical course: results of a 5-year population-based follow-up study (the IBSEN study). Inflamm Bowel Dis. 2006; 12(7): 543-50[DOI][PubMed]
  • 16. Kamm MA. Review article: maintenance of remission in ulcerative colitis. Aliment Pharmacol Ther. 2002; 16 Suppl 4: 21-4[PubMed]
  • 17. Langhorst J, Hofstetter A, Wolfe F, Hauser W. Short-term stress, but not mucosal healing nor depression was predictive for the risk of relapse in patients with ulcerative colitis: a prospective 12-month follow-up study. Inflamm Bowel Dis. 2013; 19(11): 2380-6[DOI][PubMed]
  • 18. Bessissow T, Lemmens B, Ferrante M, Bisschops R, Van Steen K, Geboes K, et al. Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing. Am J Gastroenterol. 2012; 107(11): 1684-92[DOI][PubMed]
  • 19. Yamamoto T, Shiraki M, Bamba T, Umegae S, Matsumoto K. Fecal calprotectin and lactoferrin as predictors of relapse in patients with quiescent ulcerative colitis during maintenance therapy. Int J Colorectal Dis. 2014; 29(4): 485-91[DOI][PubMed]
  • 20. Anna K, Oleg K, Albina L, Asfold P, Irina R, Alevtina C. P-061 Latent Iron Deficiency is a Predictor of Early Relapse of Ulcerative Colitis. Inflamm Bowel Dis. 2014; 20[DOI]
  • 21. Park BJ, Lee KJ, Hwang JC, Sin SJ, Chung JY, Cho SW. [Relapse rates of ulcerative colitis in remission and factors related to relapse]. Korean J Gastroenterol. 2008; 52(1): 21-6[PubMed]
  • 22. Hoie O, Wolters F, Riis L, Aamodt G, Solberg C, Bernklev T, et al. Ulcerative colitis: patient characteristics may predict 10-yr disease recurrence in a European-wide population-based cohort. Am J Gastroenterol. 2007; 102(8): 1692-701[DOI][PubMed]
  • 23. Yamakawa K, Yoshino T, Nishimura S, Watanabe K, Yazumi S. The predictive factor for relapse of ulcerative colitis in patients with endoscopic mucosal healing. J Crohns Colitis. 2015; 9
  • 24. Shen J, Zuo ZX, Mao AP. Effect of probiotics on inducing remission and maintaining therapy in ulcerative colitis, Crohn's disease, and pouchitis: meta-analysis of randomized controlled trials. Inflamm Bowel Dis. 2014; 20(1): 21-35[DOI][PubMed]
  • 25. Hedin CR, Mullard M, Sharratt E, Jansen C, Sanderson JD, Shirlaw P, et al. Probiotic and prebiotic use in patients with inflammatory bowel disease: a case-control study. Inflamm Bowel Dis. 2010; 16(12): 2099-108[DOI][PubMed]
  • 26. Miele E, Pascarella F, Giannetti E, Quaglietta L, Baldassano RN, Staiano A. Effect of a probiotic preparation (VSL#3) on induction and maintenance of remission in children with ulcerative colitis. Am J Gastroenterol. 2009; 104(2): 437-43[DOI][PubMed]
  • 27. Mercer M, Brinich MA, Geller G, Harrison K, Highland J, James K, et al. How patients view probiotics: findings from a multicenter study of patients with inflammatory bowel disease and irritable bowel syndrome. J Clin Gastroenterol. 2012; 46(2): 138-44[DOI][PubMed]
  • 28. Dignass AU, Eriksson A, Kilander A, Pukitis A, Rhodes JM, Vavricka S. Clinical trial: five or ten cycles of granulocyte-monocyte apheresis show equivalent efficacy and safety in ulcerative colitis. Aliment Pharmacol Ther. 2010; 31(12): 1286-95[DOI][PubMed]
  • 29. Sands BE, Katz S, Wolf DC, Feagan BG, Wang T, Gustofson LM, et al. A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn's disease. Gut. 2013; 62(9): 1288-94[DOI][PubMed]
  • 30. Arias MT, Vande Casteele N, Vermeire S, de Buck van Overstraeten A, Billiet T, Baert F, et al. A panel to predict long-term outcome of infliximab therapy for patients with ulcerative colitis. Clin Gastroenterol Hepatol. 2015; 13(3): 531-8[DOI][PubMed]
Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments