Annals of Colorectal Research

Published by: Kowsar

Non-Alcoholic Fatty Liver Disease as a Risk for Colorectal Cancer Development and the Role of Screening Colonoscopy in Clinical Practice

Cosmas Rinaldi Adithya Lesmana 1 , 2 , * , Mutiara Lirendra 3 and Laurentius Adrianto Lesmana 1
Authors Information
1 Digestive Disease and GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia
2 Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia
3 Medical Faculty, Tarumanagara University, Jakarta, Indonesia
Article information
  • Annals of Colorectal Research: 7 (1); e88488
  • Published Online: March 6, 2019
  • Article Type: Review Article
  • Received: December 31, 2018
  • Accepted: January 18, 2019
  • DOI: 10.5812/acr.88488

To Cite: Lesmana C R A, Lirendra M, Adrianto Lesmana L. Non-Alcoholic Fatty Liver Disease as a Risk for Colorectal Cancer Development and the Role of Screening Colonoscopy in Clinical Practice, Ann Colorectal Res. Online ahead of Print ; 7(1):e88488. doi: 10.5812/acr.88488.

Copyright © 2019, Annals of Colorectal Research. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License ( which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
1. Context
2. Colorectal Cancer: Pathogenesis, Risk Factors, Screening, and Diagnosis
3. Non-Alcoholic Fatty Liver Disease (NAFLD) and Risk of CRC Development
4. Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Screening Colonoscopy
5. Conclusions
  • 1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. doi: 10.3322/caac.21492. [PubMed: 30207593].
  • 2. Kolligs FT. Diagnostics and epidemiology of colorectal cancer. Visc Med. 2016;32(3):158-64. doi: 10.1159/000446488. [PubMed: 27493942]. [PubMed Central: PMC4945785].
  • 3. Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683-91. doi: 10.1136/gutjnl-2015-310912. [PubMed: 26818619].
  • 4. European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016;64(6):1388-402. doi: 10.1016/j.jhep.2015.11.004. [PubMed: 27062661].
  • 5. Lesmana CR, Pakasi LS, Inggriani S, Aidawati ML, Lesmana LA. Development of non-alcoholic fatty liver disease scoring system among adult medical check-up patients: A large cross-sectional and prospective validation study. Diabetes Metab Syndr Obes. 2015;8:213-8. doi: 10.2147/DMSO.S80364. [PubMed: 25960672]. [PubMed Central: PMC4410820].
  • 6. Loomba R, Sanyal AJ. The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol. 2013;10(11):686-90. doi: 10.1038/nrgastro.2013.171. [PubMed: 24042449].
  • 7. Touzin NT, Bush KN, Williams CD, Harrison SA. Prevalence of colonic adenomas in patients with nonalcoholic fatty liver disease. Therap Adv Gastroenterol. 2011;4(3):169-76. doi: 10.1177/1756283X11402118. [PubMed: 21694801]. [PubMed Central: PMC3105612].
  • 8. Wong VW, Wong GL, Tsang SW, Fan T, Chu WC, Woo J, et al. High prevalence of colorectal neoplasm in patients with non-alcoholic steatohepatitis. Gut. 2011;60(6):829-36. doi: 10.1136/gut.2011.237974. [PubMed: 21339204].
  • 9. Shen H, Lipka S, Kumar A, Mustacchia P. Association between nonalcoholic fatty liver disease and colorectal adenoma: A systemic review and meta-analysis. J Gastrointest Oncol. 2014;5(6):440-6. doi: 10.3978/j.issn.2078-6891.2014.061. [PubMed: 25436123]. [PubMed Central: PMC4226833].
  • 10. Cappell MS. The pathophysiology, clinical presentation, and diagnosis of colon cancer and adenomatous polyps. Med Clin North Am. 2005;89(1):1-42. vii. doi: 10.1016/j.mcna.2004.08.011. [PubMed: 15527807].
  • 11. Menzelio D. De excescentals verrucosa cristosis in intestinins crassis dysentarium passi observatis. Acta Med Berolinensium. 1721;4:68-71.
  • 12. Veale AMO. Eugenics laboratory memoir series: Volume 40, intestinal polyposis (eugenics laboratory memorial). New York: Cambridge University Press; 1965.
  • 13. Arcidiacono B, Iiritano S, Nocera A, Possidente K, Nevolo MT, Ventura V, et al. Insulin resistance and cancer risk: An overview of the pathogenetic mechanisms. Exp Diabetes Res. 2012;2012:789174. doi: 10.1155/2012/789174. [PubMed: 22701472]. [PubMed Central: PMC3372318].
  • 14. Stojsavljević S, Jukić LV, Kralj D, Duvnjak M. The relationship between insulin resistance and colon cancer. End Oncol Metabolism. 2016;2(1):24-33.
  • 15. Jee SH, Kim HJ, Lee J. Obesity, insulin resistance and cancer risk. Yonsei Med J. 2005;46(4):449-55. doi: 10.3349/ymj.2005.46.4.449. [PubMed: 16127767]. [PubMed Central: PMC2815827].
  • 16. Wolin KY, Carson K, Colditz GA. Obesity and cancer. Oncologist. 2010;15(6):556-65. doi: 10.1634/theoncologist.2009-0285. [PubMed: 20507889]. [PubMed Central: PMC3227989].
  • 17. Martinez-Useros J, Garcia-Foncillas J. Obesity and colorectal cancer: Molecular features of adipose tissue. J Transl Med. 2016;14:21. doi: 10.1186/s12967-016-0772-5. [PubMed: 26801617]. [PubMed Central: PMC4722674].
  • 18. Moghaddam AA, Woodward M, Huxley R. Obesity and risk of colorectal cancer: A meta-analysis of 31 studies with 70,000 events. Cancer Epidemiol Biomarkers Prev. 2007;16(12):2533-47. doi: 10.1158/1055-9965.EPI-07-0708. [PubMed: 18086756].
  • 19. Vega P, Valentin F, Cubiella J. Colorectal cancer diagnosis: Pitfalls and opportunities. World J Gastrointest Oncol. 2015;7(12):422-33. doi: 10.4251/wjgo.v7.i12.422. [PubMed: 26690833]. [PubMed Central: PMC4678389].
  • 20. Rex DK, Boland CR, Dominitz JA, Giardiello FM, Johnson DA, Kaltenbach T, et al. Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-society task force on colorectal cancer. Am J Gastroenterol. 2017;112(7):1016-30. doi: 10.1038/ajg.2017.174. [PubMed: 28555630].
  • 21. Buzzetti E, Pinzani M, Tsochatzis EA. The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). Metabolism. 2016;65(8):1038-48. doi: 10.1016/j.metabol.2015.12.012. [PubMed: 26823198].
  • 22. Arslan N. Obesity, fatty liver disease and intestinal microbiota. World J Gastroenterol. 2014;20(44):16452-63. doi: 10.3748/wjg.v20.i44.16452. [PubMed: 25469013]. [PubMed Central: PMC4248188].
  • 23. Fiori E, Lamazza A, De Masi E, Schillaci A, Crocetti D, Antoniozzi A, et al. Association of liver steatosis with colorectal cancer and adenoma in patients with metabolic syndrome. Anticancer Res. 2015;35(4):2211-4. [PubMed: 25862880].
  • 24. Bhatt BD, Lukose T, Siegel AB, Brown RS Jr, Verna EC. Increased risk of colorectal polyps in patients with non-alcoholic fatty liver disease undergoing liver transplant evaluation. J Gastrointest Oncol. 2015;6(5):459-68. doi: 10.3978/j.issn.2078-6891.2015.050. [PubMed: 26487938]. [PubMed Central: PMC4570908].
  • 25. Hwang ST, Cho YK, Park JH, Kim HJ, Park DI, Sohn CI, et al. Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps. J Gastroenterol Hepatol. 2010;25(3):562-7. doi: 10.1111/j.1440-1746.2009.06117.x. [PubMed: 20074156].
  • 26. Chen QF, Zhou XD, Fang DH, Sun YJ, Zhao Q, Huang JH, et al. Impact of non-alcoholic fatty liver disease and smoking on colorectal polyps. Oncotarget. 2017;8(43):74927-35. doi: 10.18632/oncotarget.20462. [PubMed: 29088835]. [PubMed Central: PMC5650390].
  • 27. Yang YJ, Bang CS, Shin SP, Baik GH. Clinical impact of non-alcoholic fatty liver disease on the occurrence of colorectal neoplasm: Propensity score matching analysis. PLoS One. 2017;12(8). e0182014. doi: 10.1371/journal.pone.0182014. [PubMed: 28777831]. [PubMed Central: PMC5544218].

Featured Image:

Creative Commons License Except where otherwise noted, this work is licensed under Creative Commons Attribution Non Commercial 4.0 International License .

Search Relations:



Create Citiation Alert
via Google Reader

Readers' Comments